Eric Goetzman is an associate professor of pediatrics at the University of Pittsburgh School of Medicine in the Division of Genetic and Genomic Medicine. He also holds a secondary appointment in the Department of Genetics at the University of Pittsburgh School of Public Health. Goetzman received his Bachelor of Arts degree from the University of Minnesota-Morris and his Doctor of Philosophy degree from the University of Alabama-Birmingham. He completed two years of post-doctoral research at the Mayo Clinic before moving to Pittsburgh in 2004. Following completion of his training he joined the faculty of the Department of Pediatrics in 2006. Goetzman’s research interests are in the areas of metabolism and mitochondrial function, with a specific focus on fat metabolism. His research has enhanced our understanding of how post-translational modifications of metabolic enzymes controls their activity and function. His work is advancing the use of alternative dietary fats for the treatment of metabolic disorders. He has published more than 65 articles, reviews, and chapters in this area and related topics.
- BS, Psychology/Pre-Med, University of Minnesota-Morris, 1994
- PhD, Medical Genetics, University of Alabama-Birmingham, 2002
- Postdoctoral Fellowship, Mayo Clinic, 2002-2004
- Postdoctoral Fellowship, UPMC Children's Hospital of Pittsburgh, 2004-2006
Goetzman ES, Vockley J. Lysine acylation causes collateral damage in inborn errors of metabolism. Sci Transl Med. 2022 May 25;14(646). doi: 10.1126/scitranslmed.abq4863. PMID: 35613282.
Goetzman E, Gong Z, Rajasundaram D, Muzumdar I, Goodchild T, Lefer D, Muzumdar R. Serum Metabolomics Reveals Distinct Profiles during Ischemia and Reperfusion in a Porcine Model of Myocardial Ischemia-Reperfusion. Int J Mol Sci. 2022 Jun 16;23(12):6711. doi: 10.3390/ijms23126711. PMID: 35743153; PMCID: PMC9223436.
Bharathi SS, Zhang BB, Paul E, Zhang Y, Schmidt AV, Fowler B, Wu Y, Tiemeyer M, Inamori KI, Inokuchi JI, Goetzman ES. GM3 synthase deficiency increases brain glucose metabolism in mice. Mol Genet Metab. 2022 Oct 28;137(4):342-348. doi: 10.1016/j.ymgme.2022.10.006. PMID: 36335793.
Airik M, Arbore H, Childs E, Huynh AB, Phua YL, Chen CW, Aird K, Bharathi S, Zhang B, Conlon P, Kmoch S, Kidd K, Bleyer AJ, Vockley J, Goetzman E, Wipf P, Airik R. Mitochondrial ROS Triggers KIN Pathogenesis in FAN1-Deficient Kidneys. Antioxidants (Basel). 2023 Apr 8;12(4):900. doi: 10.3390/antiox12040900. PMID: 37107275; PMCID: PMC10135478.
Rutledge C, Enriquez A, Redding K, Lopez M, Mullett S, Gelhaus SL, Jurczak M, Goetzman E, Kaufman BA. Liraglutide Protects Against Diastolic Dysfunction and Improves Ventricular Protein Translation. Cardiovasc Drugs Ther. 2023 Jun 29. doi: 10.1007/s10557-023-07482-9. Epub ahead of print. PMID: 37382868.
Rutledge CA, Lagranha C, Chiba T, Redding K, Stolz DB, Goetzman E, Sims-Lucas S, Kaufman BA. Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest. J Mol Cell Cardiol Plus. 2023 Jun; 4:100034. doi: 10.1016/j.jmccpl.2023.100034. Epub 2023 Apr 5. PMID: 37425219; PMCID: PMC10327679.
Goetzman E, Gong Z, Zhang B, Muzumdar R. Complex II Biology in Aging, Health, and Disease. Antioxidants (Basel). 2023 Jul 24;12(7):1477. doi: 10.3390/antiox12071477. PMID: 37508015; PMCID: PMC10376733.
Schmidt AV, Monga SP, Prochownik EV, Goetzman ES. A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma. Int J Mol Sci. 2023 Aug 9;24(16):12618. doi: 10.3390/ijms241612618. PMID: 37628798; PMCID: PMC10454864.
Burton JB, Silva-Barbosa A, Bons J, Rose J, Pfister K, Simona F, Gandhi T, Reiter L, Bernhardt O, Hunter CL, Goetzman ES, Sims-Lucas S, Schilling B. Substantial downregulation of mitochondrial and peroxisomal proteins during acute kidney injury revealed by data-independent acquisition proteomics. Proteomics. 2023 Sep 29:e2300162. doi: 10.1002/pmic.202300162. Epub ahead of print. PMID: 37775337.
Anne C. S. Barbosa, Katherine E. Pfister, Takuto Chiba, Joanna Bons, Jacob P. Rose, Jordan B. Burton, Christina D. King, Amy O’Broin, Victoria Young, Bob Zhang, Bharathi Sivakama, Alexandra V. Schmidt, Rebecca Uhlean, Birgit Schilling, Eric S. Goetzman**, Sunder Sims-Lucas**. Dicarboxylic acid supplementation protects from acute kidney injury via stimulation of renal peroxisomal activity. J Am Soc Nephrol. 2023 In press.
