Possible Rotation Projects:
CREBRF and Metabolic Adaptation
Human Determinants of Energy Substrate Homeostasis
Adipose Tissue, Mobility, and Metabolic Resilience
Training Technologies Used:
Human cohort studies and clinical phenotyping
Bioinformatics, computational biology, and data science
Multi-omics (transcriptomics, proteomics, metabolomics)
Systems biology and integrative physiology
Molecular and cellular metabolism
Cell culture and hiPSC-derived model systems
Mouse models of metabolic disease
Genetic engineering and functional genomics
Scientific communication, manuscript preparation, and grant writing
- BA, Cornell University College of Arts and Sciences
- MD, Weill Cornell Medical College of Cornell University
- Residency, New York Presbyterian Hospital - Cornell Campus
- Fellowship, Division of Endocrinology, Department of Medicine, Beth Israel Deaconess
- Instructor, Division of Endocrinology, Department of Medicine, Beth Israel Deaconess
Kershaw EE, Hamm JK, Verhagen LA, Peroni O, Katic M, Flier JS. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes. 2006;55(1):148-157. PMID: 16380488.
Minster RL, Hawley NL, Su CT, Sun G, Kershaw EE, et al. A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nat Genet. 2016;48(9):1049-1054. PMID: 27455349.
Kanshana JS, Mattila PE, Ewing MC, Wood AN, Schoiswohl G, Meyer AC, et al. A murine model of the human CREBRF R457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. PLoS One. 2021;16(9):e0251895. PMID: 34520472.
Carlson JC, Krishnan M, Rosenthal SL, Russell EM, Zhang JZ, Hawley NL, et al. A stop-gain variant in BTNL9 is associated with atherogenic lipid profiles. HGG Adv. 2022;4(1):100155. PMID: 36340932.
Rosenson RS, Gaudet D, Ballantyne CM, Baum SJ, Bergeron J, Kershaw EE, et al. Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial. Nat Med.2023;29(3):729-737. PMID: 36879129.
Yeo RX, Mau T, Ross ZM, Edenhoffer NP, Liu J, Barnes HN, et al. Investigating the role of adipose tissue in mobility and aging: design and methods of the Adipose Tissue ancillary to the Study of Muscle, Mobility, and Aging (SOMMA-AT). J Gerontol A Biol Sci Med Sci. 2025;80(6):glaf015. PMID: 39886989.
Loft A, Emont MP, Weinstock A, Divoux A, Ghosh A, Wagner A, et al. Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution. Nat Metab. 2025;7(5):875-894. PMID: 40360756.
Ahn C, Tamburini I, Sanford JA, Zhou M, Gamie F, Yeo RX, et al. Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults. Mol Metab. 2025;99:102213. PMID: 40675551.
Dubé JJ, Barnes HN, Ross ZM, Murthy N, Gligorijevic N, Basantani MK, et al. Adiposity and Cognitive Performance in Older Men and Women from the Study of Muscle, Mobility and Aging (SOMMA). J Gerontol A Biol Sci Med Sci. 2026. PMID: 42747296.
Saydmohammed M, Jha A, Mahajan V, Gavlock D, Shun TY, DeBiasio R, et al. Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors. Exp Biol Med (Maywood). 2021;246(22):2420-2441. PMID: 33957803.
Pubmed link: https://www.ncbi.nlm.nih.gov/myncbi/erin.kershaw.1/bibliography/41144625/public/
The Kershaw Lab investigates the mechanisms that maintain whole-body energy substrate homeostasis and how their disruption contributes to obesity, diabetes, cardiovascular disease, and related metabolic disorders. A central focus is understanding how adipose tissue, lipids, and inter-organ communication regulate metabolic health, resilience, and adaptation across diverse physiological and pathological states. Our multidisciplinary research program integrates human cohort studies, clinical investigation, systems biology, multi-omics, and experimental models to identify mechanisms governing glucose and lipid homeostasis. Through these studies, we seek to advance the prevention and treatment of metabolic disease while defining biological pathways that promote long-term metabolic health and resilience. Students in the laboratory receive training spanning molecular metabolism, human genetics, bioinformatics, multi-omics, systems biology, and clinical/translational research.
