Possible Rotation Projects:
Study of the mechanism in RGC development
Stem cell-derived RGC differentiation
Gene therapy for axon regeneration
Training Technologies Used:
- Human retinal organoid differentiation, AAV gene therapy in animal model, optic nerve crush, electroretinography, OCT.
- 2016-2020 Stanford University, Postdoc in Ophthalmology
- 2011-2015 University of Colorado Anschutz Medical Campus, PhD in Toxicology
- 2006-2008 National Tsing Hua University, MS in Biotechnology
- 2002-2006 National Dong Hwa University, BS in Life Science
Chang KC#,*,Hertz JY#, Zhang X#, Jin XL, Shaw P, Derosa BA, Li JY, Venugopalan P, Valenzuela DA, Patel RD, Russano KR, Alshamekh SA, Sun C, Tenerelli K, Li C, Velmeshev D, Cheng Y, Boyce TM, Dreyfuss A, Uddin MS, Muller KJ, Dykxhoorn DM and Goldberg JL “Novel regulatory mechanisms for the SoxC transcriptional network required for visual pathway development” J Neurosci. 2017, 37(19):4967-4981 (# Co-first author).
Chang KC*, SunC, Cameron EG, Madaan A, Wu S, Xia X, Zhang X, Tenerelli K, Nahmou M, Knasel CM, Russano KR, Hertz J and Goldberg JL“Opposing effects of growth and differentiation factor in cell fate specification” Current Biology. 2019, 29(12):1963-1975.
Zhang X, Tenerelli K, Wu S, Xia X, Sun C, Galvao J, Venugopalan P, Li C, Madaan A, Goldberg JL* and Chang KC* “Cell transplantation of retinal ganglion cells derived from hESCs” Restor Neurol Neurosci. 2019, 38(2):131-140.
Chang KC*, Bian M, Xia X, Madaan A, Sun C, Wang Q, Li L, Nahmou M, Noro T, Yokota S, Galvao J, Kreymerman A, Tanasa B, Hu Y, Goldberg JL* “Post-translational modification of Sox11 regulates RGC survival and axon regeneration” eNeuro, 2021, 8(1).
My research focuses on restoring vision loss, especially caused by glaucoma and optic neuropathy. I will investigate the regulatory mechanism of RGC differentiation and apply the findings to gene and stem cell therapies.
