Possible Rotation Projects:
Project 1 -Explore novel regulatory mechanisms between aging-related and virus-specific infected ECs and immune cells.
Project 2 - Identify novel key transcription factors regulating aging related and virus-specific induced dysfunctional immunomodulatory ECs.
Project 2 - Examining Clinical Sub-phenotypes and Identifying Biomarkers for Patients with Long COVID.
Technologies Used:
- Single-cell RNA sequence and spatial in situ single-cell transcriptomics analysis and integration, multi-omics analysis, machine learning.
- In vitro cell culture, in vivo mouse models, and ex vivo lung models.
Education & Training
- • Ph.D. in Pharmacology, 2013, University of Rochester, NY, USA
- • M.D. in Medicine, 2003, Medical School of Fudan University, Shanghai, China
Recent Publications
- Ao Y, Bagale K, Hu S, Mostafa A, Ye C, Salvadore K, Gibson G, Pineda R, Lu J, Covitz R, Chan D, Langlois R, Zimring JC, Duprex P, St Croix CM, Alcorn JF, Rehman J, Koenigshoff M, Martinez-Sobrido L, Xing J, Zhang L. Pulmonary Microvascular Endothelial Antigen Presentation Activates resident CD8(+) T Cells to Restrain Influenza Lung Injury. Res Sq. 2026 Jan 8; PubMed Central PMCID: PMC12803330.
- Skeeters S, Bagale K, Stepanyuk G, Thieker D, Aguhob A, Chan KK, Dutzar B, Shalygin S, Shajahan A, Yang X, DaRosa PA, Frazier E, Sauer MM, Bogatzki L, Byrnes-Blake KA, Song Y, Azadi P, Tarcha E, Zhang L, Procko E. Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation. Mol Ther Methods Clin Dev. 2024 Sep 12;32(3):101301. PubMed Central PMCID: PMC11342882.
- Zhang L, Gao S, White Z, Dai Y, Malik AB, Rehman J. Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations. JCI Insight. 2022 Jun 8;7(11) PubMed Central PMCID: PMC9220950.
- Zhang L, Narayanan KK, Cooper L, Chan KK, Skeeters SS, Devlin CA, Aguhob A, Shirley K, Rong L, Rehman J, Malik AB, Procko E. An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS-CoV-2. EMBO Mol Med. 2022 Nov 8;14(11):e16109. PubMed Central PMCID: PMC9539395.
- Zhang L, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E, Rehman J, Malik AB. Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants. Nat Chem Biol. 2022 Mar;18(3):342-351. PubMed Central PMCID: PMC8885411.
- link to full list of publications
https://www.ncbi.nlm.nih.gov/myncbi/lianghui.zhang.1/bibliography/public/
Research Interests
The Zhang Lab investigates the immunopathogenic mechanisms of respiratory viruses-induced lung injury, focusing on interactions between endothelial immunomodulation and immune cell activation. The team use mechanism-based findings to guide development of translational therapies for respiratory viruses-induced lung injury.
