Possible Rotation Projects:
- Role of cell-specific Nrf2 activity in glomerular and tubular kidney injuries
- Role of renal nerves in kidney disease pathogenesis
- B.S. Biology, Georgetown University, 1999
- Ph.D. Cellular and Molecular Pathology, University of Pittsburgh, 2007
- M.D. Medicine, University of Pittsburgh, 2007
- Internal Medicine Residency, University of Pittsburgh Medical Center, 2010
- Nephrology Fellowship, University of Pittsburgh, 2012
Chen Q, George MW, McMahon B, Rosenthal JA, Kim K, Tan RJ. Super-Resolution Ultrasound to Assess Kidney Vascular Changes in Humans With Kidney Disease. Am J Kidney Dis. 2025 Mar;85(3):393-395. doi: 10.1053/j.ajkd.2024.06.021. Epub 2024 Aug 16. PMID: 39154889; PMCID: PMC12914559.
Bondi CD, Hartman HL, Tan RJ. NRF2 in kidney physiology and disease. Physiol Rep. 2024 Mar;12(5):e15961. doi: 10.14814/phy2.15961. PMID: 38418382; PMCID: PMC10901725.
Bondi CD, Rush BM, Hartman HL, Wang J, Al-Bataineh MM, Hughey RP, Tan RJ. Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury. Antioxidants (Basel). 2022 Sep 14;11(9):1810. doi: 10.3390/antiox11091810. PMID: 36139884; PMCID: PMC9495756.
Mutchler SM, Hasan M, Kohan DE, Kleyman TR, Tan RJ. Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury. Int J Mol Sci. 2021 Oct 9;22(20):10914. doi: 10.3390/ijms222010914. PMID: 34681576; PMCID: PMC8535410.
Chen Q, Yu J, Rush BM, Stocker SD, Tan RJ, Kim K. Ultrasound super-resolution imaging provides a noninvasive assessment of renal microvasculature changes during mouse acute kidney injury. Kidney Int. 2020 Aug;98(2):355-365. doi: 10.1016/j.kint.2020.02.011. Epub 2020 Mar 3. PMID: 32600826; PMCID: PMC7387159.
Tan RJ, Li Y, Rush BM, Cerqueira DM, Zhou D, Fu H, Ho J, Beer Stolz D, Liu Y. Tubular injury triggers podocyte dysfunction by β-catenin-driven release of MMP-7. JCI Insight. 2019 Dec 19;4(24):e122399. doi: 10.1172/jci.insight.122399. PMID: 31743113; PMCID: PMC6975262.
Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y. Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Sci Rep. 2016 Nov 2;6:36185. doi: 10.1038/srep36185. PMID: 27804998; PMCID: PMC5090361.
Tan RJ, Zhou D, Xiao L, Zhou L, Li Y, Bastacky SI, Oury TD, Liu Y. Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. J Am Soc Nephrol. 2015 Oct;26(10):2447-59. doi: 10.1681/ASN.2014060613. Epub 2015 Feb 2. PMID: 25644107; PMCID: PMC4587687.
We are interested in the pathogenesis of acute and chronic kidney disease. Using a variety of techinques spanning whole animal (rodent) to molecular analyses, we investigate the pathways causing kidney dysfunction in tubular and glomerular disorders. Our work has focused on the KEAP1/NRF2 pathway on tubular, endothelial, and podocyte cells in the kidney. We also evaluate the unique role of renal nerves in disease pathogenesis.
