Training Technologies Used:
- Transgenic mouse, human iPS cells, retinal organoid, microfluidic chambers, to model diseases that affect the visual system.
Possible Rotation Projects:
- Cell co-culture of human retinal organoids with tumor cells, drug discovery in mouse model for progressive retinal and optic nerve degeneration.
- Postdoctoral training, Boston Children’s Hospital/Harvard Medical School, Boston
- PhD in Neuroscience, UFRJ/ICB – Brazil and Boston Children’s Hospital/Harvard Medical School, USA
- Master of Science, Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Ciência Biomédica (ICB) – Brazil
Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. de Lima S, Koriyama Y, Kurimoto T, Oliveira JT, Yin Y, Li Y, Gilbert HY, Fagiolini M, Martinez AM, Benowitz L. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9149-54. doi: 10.1073/pnas.1119449109. Epub 2012 May 21.
Combinatorial therapy stimulates long-distance regeneration, target reinnervation, and partial recovery of vision after optic nerve injury in mice. de Lima S, Habboub G, Benowitz LI .Int Rev Neurobiol. 2012;106:153-72. doi: 10.1016/B978-0-12-407178-0.00007-7.
Reassembly of Excitable Domains after CNS Axon Regeneration. Marin MA, de Lima S, Gilbert HY, Giger RJ, Benowitz L, Rasband MN. J Neurosci. 2016 Aug 31;36(35):9148-60. doi: 10.1523/JNEUROSCI.1747-16.2016.
Rescuing axons from degeneration does not affect retinal ganglion cell death. De Lima S, et al. Braz J Med Biol Res. 2016;49(4):e5106. doi: 10.1590/1414-431X20155106. Epub 2016 Mar 18.
Editorial: Promoting nervous system regeneration by treatments targeting neuron-glia interactions. De Lima S, Mietto BS, Ribas VT, Ribeiro-Resende VT, Oliveira ALR, Park KK. Front Cell Neurosci. 2024 Jan 11;17:1355469. doi: 10.3389/fncel.2023.1355469. eCollection 2023.
The de Lima Lab investigates neuroprotection and regeneration of cells in the retina responsible for carrying the information perceived by the eye all the way to the brain - the retinal ganglion cells (RGC) - focusing on the disease model for optic pathway gliomas caused by the genetic disorder Neurofibromatosis type 1 (NF1-OPG). Our aim is to investigate mechanisms that promote survival and regeneration of RGCs and explore therapeutic targets.
